GOTHENBURG, Sweden--23 May--PRNewswire-AsiaNet/ InfoQuest
Results of a new analysis from the largest-ever morbi-mortality study of treatments for chronic heart failure show that the heart rate lowering agent Procoralan(R) (ivabradine) significantly improves health related quality of life.[1] The new data from SHIFT (Systolic Heart Failure Treatment with the If Inhibitor Ivabradine Trial), presented for the first time today at the Heart Failure Congress 2011, are particularly important as quality of life is greatly impaired in patients with congestive heart failure.
"Improving survival and alleviating patient suffering are the major goals in the management of heart failure patients", points out SHIFT co-chairman Professor Karl Swedberg from the University of Gothenburg. "However, currently prescribed heart failure treatments that prolong life such as beta-blockers only improve quality of life for heart failure patients modestly, if at all, while therapies such as diuretics that significantly improve quality of life have no demonstrable effect on survival. We need new therapies such as ivabradine that improve quality of life and survival".
The SHIFT quality of life study involved 1944 patients with chronic heart failure from 24 countries who were randomised to receive either Procoralan(R) or placebo on top of standard heart failure therapy. Health related quality of life was assessed for two years using the Kansas City Cardiomyopathy Questionnaire (KCCQ), a validated, disease-specific measure of functional status and quality of life.[2] The KCCQ is a self-administered questionnaire, that quantifies various aspects of day-to-day life like physical limitations, symptoms, self-efficacy, social interference in chronic heart failure patients.
An improvement was observed in the Procoralan(R) group. In a specific analysis that excluded patients who died, the increase, in clinical summary score (CSS) reporting more on clinical symptoms and overall summary score (OSS) including clinical and social aspects, was up to twice more in the Procoralan group.
These new results complement the main findings of the SHIFT study which showed that Procoralan(R) reduced the risk of hospitalisation due to worsening heart failure by over a quarter (26%, p