BANGKOK, July 12 -- PRNewswire/ AsiaNet
Healthcare professionals and patients map out steps towards
optimal use of FUZEON(R)
Despite the clear benefits for patients and the high rates of resistance in
the west, new research has shown that currently only 1 out of 5 eligible
patients is benefiting from the latest HIV breakthrough, FUZEON(R) (enfuvirtide
or T-20)(1), primarily due to the need to inject the drug. At the International
AIDS Conference in Bangkok today, new guidance will be presented on how
healthcare professionals and patients can work together to effectively
incorporate FUZEON into patients' daily treatment routine.
"FUZEON is a revolutionary therapy and for the majority of patients the
significant improvements in health far outweigh the burden of the injection. It
is alarming that many of these patients offered FUZEON are not accepting the
offer due to the fear of injection and are missing out on the modern era of HIV
therapy," comments Professor Joep Lange, President of the International AIDS
Society.
Comprehensive FUZEON benefits seen by 3 months and maintained at 2 years(2)
Dramatic FUZEON virological benefits can be seen as early as 1 week. Within
just 3 months, FUZEON patients are twice as likely to achieve undetectable
levels of HIV compared to those who are not taking FUZEON. Furthermore, data
show these benefits are maintained at 2 years. FUZEON patients also reported
approximately half the incidence of diarrhoea, a common and often debilitating
side effect associated with HIV therapy.
"We urge physicians and nurses to work closely with their patients during
the first 3 months of FUZEON therapy, by which time dramatic benefits should be
seen and self injection should have become routine," comments Dr Mike Youle,
Royal Free Hospital, London.
The pivotal role of physicians and nurses
"It is essential that, as physicians, we present FUZEON to all triple class
experienced patients, balancing the remarkable improvements in viral load, CD4
count and quality of life, with the need for self-injection. Our challenge is
to identify ways in which we can improve the offer of FUZEON to help patients
understand how FUZEON could improve their quality of life and in all likelihood
live longer as a result of sustained viral suppression," concludes Dr Youle.
Nurses have a pivotal role in helping patients to understand the offer of
FUZEON and incorporate injections into their daily lives. Dominick Varsalone, a
nurse from the North Jersey Community Research Initiative, New Jersey,
comments: "The true success of our empowerment programme can be gauged by the
fact that, of the 64 patients prescribed FUZEON in our clinic since drug
launch, 91% are still on FUZEON. My FUZEON patients are greatly motivated by
the improvements in their health, sometimes just a week after beginning
therapy. FUZEON experienced patients are also providing invaluable support and
practical advice for new patients beginning FUZEON therapy."
Roche's continued commitment to patients
Roche has activities under way in all countries where FUZEON is available
to help educate and support patients with their therapy. These include
nurse-to-patient and patient-to-patient support initiatives to help coach
patients through the first 3 critical months of therapy to provide their best
chance for sustained success with FUZEON.
A closer look at the 96 week data
A closer look at the 96 week data confirm that FUZEON based regimens
continue to provide a significant, durable response to pre-treated HIV patients
over 2 years of treatment. The safety profile was confirmed with no changes in
the adverse event profile between 1 and 2 years of therapy. Consistent and
continuous improvements in immune strength were seen in FUZEON patients over 96
weeks. FUZEON patients remained twice as likely to show undetectable HIV as
those patients who did not receive FUZEON. In addition, more than half of
patients who received FUZEON completed 2 years of treatment.
HIV resistance - "ticking time bomb" in the west
"There is a disturbing misconception that 'access for all' is just a
challenge for the developing world. Access to optimal combination therapy
remains an urgent issue in the west where alarming levels of resistance to HIV
therapies is a ticking time bomb. While people continue to die from AIDS in the
western world - with more than 15,000 patients dying in the US in 2003 alone -
there is an urgent need to use all drugs currently available to provide the
most effective combination treatment for patients," commented Professor Lange.
References:
1) Data on file, survey conducted in UK, France and US 2004
2) Arast?h et al. XV IAC Bangkok, Thailand, 2004. Abstract MoOrB1058
SOURCE: Roche Pharmaceuticals
CONTACT: Alexander Watson
Ketchum
+44 7712 675 990
[email protected]
Janet Sanburg
F. Hoffmann-La Roche Ltd
+41 79 255 9414
[email protected]
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