PARIS--19 Sep--PRNewswire-AsiaNet/InfoQuest Bipolar disorder is the sixth largest cause of disability worldwide in people aged 15-44 years[1] and is commonly mistaken for other diseases such as acute depression. Consequently, people may suffer with symptoms for years before receiving appropriate treatment and up to half of all individuals with bipolar disorder may make at least one suicide attempt in their lifetime[2]. Data presented at the 19th European College of Neuropsychopharmacology in Paris has highlighted the significant impact of this disease and demonstrated the efficacy of an 'atypical' antipsychotic known as quetiapine (SEROQUEL). From the first week of the BOLDER II (BipOLar DEpRession) study, improvements in the severity of depressive symptoms (MADRS total scores[x]) weresignificantly greater with quetiapine 300 and 600 mg/d than with placebo (week 1, change from baseline with quetiapine 300 and 600 mg/d: -9.42 and -9.14, respectively; both P