New Data Examines the Effect of Adding a Statin to Optimised Treatment for Patients with Advanced Heart Failure

ข่าวต่างประเทศ Tuesday November 6, 2007 08:51 —Asianet Press Release

ORLANDO, Fla--6 Nov--PRNewswire-AsiaNet/InfoQuest New data from the CORONA study presented today at the American Heart Association 2007 Scientific Sessions showed that adding a statin to optimised heart failure treatment did not significantly improve the prognosis for patients with advanced heart failure because it could not reverse or prevent the deterioration of a failing heart. Patients taking AstraZeneca's CRESTOR(TM) (rosuvastatin) 10mg experienced an 8 percent reduction (p=0.12) in the combined primary endpoint of cardiovascular death or myocardial infarction or stroke, which was not statistically significant. This reduction was primarily driven by a decrease in atherosclerotic events, i.e. stroke and myocardial infarctions (post hoc analysis p=0.05) which is where statins have been proven to have benefit. In this study the majority of deaths were due to sudden death, or non-ischemic causes, which did not appear to be impacted by statin therapy. In addition, significantly fewer hospitalizations occurred in patients on CRESTOR compared to placebo, whether due to any cause (p=0.007), cardiovascular causes (p

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