ORLANDO, Fl.--30 Mar--PRNewswire-AsiaNet/InfoQuest
- A New Analysis From the JUPITER Trial
A new analysis from the JUPITER study shows that CRESTOR (rosuvastatin) 20mg significantly cut the risk of venous thromboembolism (VTE) by 43% (p=0.007) compared to placebo among men and women with low to normal cholesterol levels and elevated high-sensitivity C-reactive protein (hsCRP). This analysis was presented today at the 58th Annual American College of Cardiology Scientific Sessions (ACC), in Orlando Florida, and published simultaneously in the New England Journal of Medicine.
Venous thromboembolism, a serious and sometimes fatal condition, occurs when a blood clot forms in a vein. The most common form of VTE is deep vein thrombosis (DVT), which usually occurs in the 'deep veins' in the legs or pelvis. An embolism is created if the clot travels through the venous system. Blood clots lodging in the lungs are known as a pulmonary embolism (PE). Estimates suggest that at least 350,000 and as many as 600,000 Americans annually contract DVT/PE, and at least 100,000 deaths are thought to be related to these diseases each year.
Additional results of this secondary endpoint analysis of JUPITER showed rosuvastatin 20mg produced a significant 55% (p=0.004) reduction in the risk of DVT and a non-significant 23% reduction in PE (p=0.42).
"This is the first time a statin has been shown to reduce the risk of VTE in a large, randomized, prospective study," said Michael Cressman, AstraZeneca's Medical Science Director for CRESTOR, "This observed benefit appears to be additional to the reduction in CV events already demonstrated by rosuvastatin in the primary analysis of JUPITER."
Rosuvastatin 20mg was well tolerated in nearly 9,000 patients during the course of the JUPITER study.
Rosuvastatin is not indicated for the prevention of cardiovascular events or venous thromboembolism. Rosuvastatin should be used according to the prescribing information, which contains recommendations for initiating and titrating therapy according to the individual patient profile. In most countries, the usual recommended starting dose of rosuvastatin is 10 mg.
ABOUT JUPITER:
Results from the primary analysis of JUPITER (Justification for the Use of statins in Primary prevention: an Intervention Trial Evaluating Rosuvastatin), originally presented in November 2008 at the American Heart
Association's Annual Scientific Sessions, and published by the New England Journal of Medicine, showed rosuvastatin 20mg significantly reduced major cardiovascular (CV) events (combined risk of myocardial infarction, stroke, arterial revascularization, hospitalization for unstable angina, or death from CV causes) by 44%, compared to placebo (p