AMSTERDAM--1 Sep--PRNewswire-AsiaNet/ InfoQuest
Valdoxan(R)/Thymanax(R) (agomelatine) is more efficacious than both conventional selective serotonin reuptake inhibitor (SSRI) and serotonin noradrenaline reuptake inhibitor (SNRI) antidepressants, according to new data presented today at the 23rd European College of Neuropsychopharmacology (ECNP) Congress.
To view the Multimedia News Release, please click:
http://multivu.prnewswire.com/mnr/prne/valdoxan/44196/
This new data supports the unique clinical signature of Valdoxan(R), already documented by a significant and continuous improvement of the patient condition from the first days of treatment, for a true recovery of depression and effective protection against relapse.[1],[2],[3] New data[4]
The new data is a result of a pooled analysis of four multicentre, international, randomised, double-blind, parallel-group studies involving outpatients with major depressive disorder (MDD). In each of these individual studies, agomelatine demonstrated to offer a distinctive profile of efficacy leading to an improved treatment of depression.
Agomelatine was compared head-to-head with SSRI (sertraline 50-100 mg, escitalopram 10-20 mg or fluoxetine 20-40 mg) and SNRI antidepressants (venlafaxine 75-150 mg) after six to eight weeks of treatment. Efficacy was assessed using the HAM-D17 total score scale. The overall analysis included 643 patients treated with agomelatine and 657 randomised to SSRI/SNRI therapy.
Agomelatine showed significantly greater antidepressant efficacy than SSRI and SNRI comparators in terms of both HAM-D17 improvement and percentage of responders. Over the treatment period, there was a significant 1.37 point difference on the HAM-D17 total score in favour of agomelatine (p